Publications

Brian MacVicar

Tai Chao

Tai, C., Zhu, S., & Zhou, N. (2008). TRPA1: The central molecule for chemical sensing in pain pathway? Neurosci, 25(5), 1019-1021.

Zhou, C., Tai, C., Ye, H.H., Ren, X., Chen, J.G., Wang, S.Q. & Chai, Z. (2006). Interleukin -1beta downregulates the L-type Ca(2+) channel activity by depressing the expression of channel protein in cortical neurons. J Cell Physiol, 206(3), 799-806.

Zhu, S., Tai. C., MacVicar, B.A., Jia, W. & Cynader, M.S. (2008). Glutamatergic stimulation triggers rapid Krupple-like factor 4 expression in neurons and the overexpression of KLF4 sensitizes neurons to NMDA-induced caspase-3 activity. Brain Res [Epub ahead of print].

Kisilevsky, A.E., Mulligan, S., Altier, C., Iftinca, M., Varela, D., Tai, C., Hamid, J., Hameed, S., MacVicar, B.A. & Zamponi, G.W. (2008). D1 receptors physically interact with N-type calcium channel complexes to regulate channel trafficking and dendritic calcium entry. Neuron 58, 557–570. PDF

Tai, C., Hines, D.J., Choi, H.B. & MacVicar, B.A. Translocation of TRPC5 channels contributes to cholinergic-dependent plateau potentials in hippocampal CA1 neurons. Proc Natl Acad Sci USA. (submitted)

Hyun Beom Choi

Gordon GR, Choi HB, Rungta RL, Ellis-Davies GC, Macvicar BA. Brain metabolism dictates the polarity of astrocyte control over arterioles. Nature. 2008 Oct 29. [Epub ahead of print]

Wei W, Ryu JK, Choi HB, McLarnon JG. Expression and function of the P2X(7) receptor in rat C6 glioma cells. Cancer Lett. 2008 Feb 18;260(1-2):79-87.

Klegeris A, Choi HB, McLarnon JG, McGeer P. Functional ryanodine receptors are expressed by human microglia and THP-1 cells: Their possible involvement in modulation of neurotoxicity. J Neurosci Res. 2007 Aug 1;85(10):2207-15.  

Choi HB, Ryu JK, Kim SU, McLarnon JG. Modulation of the purinergic P2X7 receptor attenuates lipopolysaccharide-mediated microglial activation and neuronal damage in inflamed brain. J Neurosci. 2007 May 2;27(18):4957-68.

Lee HJ, Kim KS, Kim EJ, Choi HB, Lee KH, Park IH, Ko Y, Jeong SW, Kim SU. Brain transplantation of immortalized human neural stem cells promotes functional recovery in mouse intracerebral hemorrhage stroke model. Stem Cells. 2007 May;25(5):1204-12.

Franciosi S, Ryu JK, Choi HB, Radov L, Kim SU, McLarnon JG. Broad Spectrum Effects of 4-aminopyridine to Modulate Amyloid-Beta1-42 induced Cell Signaling and Functional Responses in Human Microglia. J Neurosci. 2006 Nov 8;26(45):11652-64.

McLarnon JG, Ryu JK, Walker DG, Choi HB. Upregulated Expression of Purinergic P2X7 Receptor in Alzheimer’s Disease and Amyloid-Beta Peptide Treated Microglia and in Peptide  Injected Rat Hippocampus. J Neuropathol Exp Neurol. 2006 Nov;65(11):1090-7.

Ryu JK, Choi HB, McLarnon JG. Combined minocycline plus pyruvate treatment enhances effects of each agent to inhibit inflammation, oxidative damage, and neuronal loss in an excitotoxic animal model of Huntington's disease. Neuroscience. 2006 141(4):1835-48.

Hong SH, Choi HB, Kim SU, McLarnon JG. Mitochondrial ligand inhibits store-operated calcium influx and COX-2 production in human microglia. J Neurosci Res. 2006 May 15;83(7):1293-8.

McLarnon JG, Choi HB, Lue LF, Walker DG, Kim SU. Perturbations in calcium-mediated signal transduction in microglia from Alzheimer's disease patients. J Neurosci Res. 2005 Aug 1;81(3):426-35.

Sattayaprasert P*, Choi HB*, Chongthammakun S, McLarnon JG. Platelet-activating factor enhancement of calcium influx and interleukin-6 expression, but not production, in human microglia. J Neuroinflammation. 2005 Apr 15;2(1):11   

Franciosi S, Choi HB, Kim SU, McLarnon JG. IL-8 enhancement of amyloid-beta (Ab1-42)-induced expression and production of pro-inflammatory cytokines and COX-2 in cultured human microglia. J Neuroimmunol. 2005 159(1-2):66-74.

Choi HB, Hong SH, Ryu JK, Kim SU, McLarnon JG. Differential activation of subtype purinergic receptors modulates Ca2+ mobilization and COX-2 in human microglia. Glia.2003 Aug;43(2):95-103.

Choi HB, Khoo C, Ryu JK, van Breemen E, Kim SU, McLarnon JG. Inhibition of lipopolysaccharide-induced cyclooxygenase-2, tumor necrosis factor-alpha and [Ca2+]i responses in human microglia by the peripheral benzodiazepine receptor ligand PK11195. J Neurochem. 2002 Nov;83(3):546-55.

Franciosi S, Choi HB, Kim SU, McLarnon JG. Interferon-gamma acutely induces calcium influx in human microglia. J Neurosci Res. 2002 Sep 1;69(5):607-13.

Cho T, Bae JH, Choi HB, Kim SS, McLarnon JG, Suh-Kim H, Kim SU, Min CK. Human neural stem cells: electrophysiological properties of voltage-gated ion channels. Neuroreport. 2002 Aug 7;13(11):1447-52.

Published books and monographs (as author)

Nakagawa E, Hatori K, Nagai A, Choi HB, Lee MA, Bang JH, Kim J, Ryu JK, Ozaki A, Lee MC, Snyder EY, Kim SU. Generation, characterization, and transplantation of immortalized human neural crest stem cells. In: Neural Stem Cells for CNS Repair, Eds: T. Zigova, E. Snyder, P. Sanberg, Humana Press, NYC, pp 89-106, 2002.

Denise Feighan

Darby, M., Kuzmiski, J.B., Panenka, W., Feighan D. & MacVicar, B.A. (2003). ATP released from astrocytes during swelling activates chloride channels. Journal of Neurophysiology, 89(4), 1870-1877. PDF

MacVicar, B.A., Feighan, D., Brown, A. & Ransom B. (2002). Intrinsic optimal signals in rat optic nerve: Role for K(+) uptake via NKCC1 and swelling of astrocytes. Glia 37(2), 114-123. PDF

Panenka, W., Jijon, H., Herx, L.M., Armstrong, J.N., Feighan D., Wei, T., Yong, V.W., Ransohoff, R.M. & MacVicar, B.A. (2001). Journal of Neuroscience, 21(18), 7135-7142. PDF

Basarsky, T.A., Feighan, D. & MacVicar, B.A. (1999). Glutamate release through volume activated channels during spreading depression. Journal of Neuroscience, 19(15), 6439-6445. PDF

Grant Gordon

Gordon, G.R., Choi, H.B., Rungta, R.L. Ellis-Davies, G.C.R. and MacVicar, B.A. (2008) Brian metabolism dictates the polarity of astrocyte control over arterioles. Nature. 456(7223):745-9. PDF

Gordon, G.R., Mulligan, S.J. and MacVicar, B.A. (2007) Astrocyte control of the cerebrovasculature. Glia. 55(12): 1214-21. PDF

McKay, B.E., Engbers, J.D., Mehaffey, W.H., Gordon, G.R., Molineux, M.L., Bains, J.S., Turner, R.W. (2007). Climbing fiber discharge regulates cerebellar functions by controlling the intrinsic characteristics of purkinje cell output. Journal of Neurophysiology.  97(4): 2590-604.

Gordon, G.R. and Bains, J.S. (2006) Can autonomic circuits learn and remember? The Journal of Physiology. 576(Pt 2): 341-7. PDF

Gordon, G.R. and Bains, J.S. (2005) Noradrenaline triggers multivesicular release at glutamatergic synapses in the hypothalamus. The Journal of Neuroscience, 25(49): 11385-95. PDF

Gordon, G.R., Baimoukhametova, D.V. Hewitt, S.A., Rajapaksha, W.R.A.K.J.S., Fisher, T.E., Bains, J.S. (2005) Norepinephrine triggers release of glial ATP to increase postsynaptic efficacy. Nature Neuroscience, 8(8): 1078-86. PDF

Gordon, G.R. and Bains, J.S. (2003) Priming of excitatory synapses by alpha-1 adrenoceptor-mediated inhibition of group III metabotropic glutamate receptors. The Journal of Neuroscience, 23(15): 6223-6231.

Book Chapters

Gordon, G.R., Mulligan, S.J. and MacVicar, B.A. (2009) Astrocyte control of blood flow. Astrocytes in (patho)physiology of the nervous system. Boston, USA: Springer (Parpura, V. and Haydon P.G., editors).

Gordon, G.R., Mulligan, S.J. and MacVicar, B.A. (2008) Glia control of blood flow. Encyclopedia of Neuroscience. Amsterdam, Netherlands: Elsevier (Adelman G and Smith B.H.editors).

Clare Howarth

Howarth, C., Peppiatt-Wildman & Attwell, D. (2009). The energy use associated with neural compuation in the cerebellum. Journal of Cerebral Blood Flow & Metabolism, Nov 1 -12.

Schölvink, M.L., Howarth, C. & Attwell, D. (2008) ‘The cortical energy needed for conscious perception.’ Neuroimage 40: 1460-8 PDF

Riera, J.J., Schousboe, A., Waagepetersen, H.S., Howarth, C. & Hyder, F. (2008) ‘The micro-architecture of the cerebral cortex: functional neuroimaging models and metabolism’ Neuroimage 40: 1436-59 PDF

Howarth, C. & Attwell, D. (2006) ‘Transports of Delight.’ Neuron 52: 224-5   PDF

Peppiatt, C*., Howarth, C*., Mobbs, P. & Attwell, D. (2006) ‘Bidirectional control of CNS capillary diameter by pericytes.’ Nature 443: 700-4  (*equal 1st author) PDF

Howarth, C., Hutton, C. & Deichmann, R. (2006) ‘Improvement of image quality of T1-weighted anatomical brain scans.’ Neuroimage 29: 930-937.PDF

Marshall, H., Howarth, C., Larkman, DJ., Herlihy, AH., Oatridge, A., Bydder, GM. (2002) ‘Contrast-enhanced magic angle MR imaging of the Achilles Tendon.’ Am J Roentgenol. 179: 187-92.

Dustin Hines

Hines, D.J., Hines, R. H., Mulligan, S. & MacVicar, B.A. (2008). Microglia processes block the spread of damage in the brain and require functional chloride channels. Glia (in press).

Thompson, R.J., Jackson, M.F., Olah, M.E., Rungta, R. L., Hines, D.J., Beazely, M.A., MacDonald, J.F. & MacVicar, B.A. (2008). Activation of Pannexin-1 hemmichannels augments aberrant bursting in the hippocampus. Science, 322, 1555-1559. PDF

Julie Robillard

Christie, B.R., Eadie, B.D., Kannangara, T.S., Robillard, J.M., Titterness, A.K. (2008) Exercising our brains: How physical activity impacts synaptic plasticity. Neuromolecular Med. 2008;10(2):47-58.

Wong, T.P., Howland, J.G., Robillard, J.M., Ge, Y., Yu, W., Olson, A.K., Brebner K., Liu, L., Phillips, A.G., Weinberg, J., Christie, B.R., Wang, Y.T. (2006) Hippocampal long-term depression mediates acute stress-induced spatial memory impairment. Proc Natl Acad Sci USA 104(27):11471-6.

Michel, F.J., Robillard, J.M., Trudeau, L.E. (2004) Regulation of rat mesencephalic GABAergic neurones through muscarinic receptors. J Physiol 556(Pt 2):429-45.

Ravi Rungta

Gordon, G.R., Choi, H.B., Rungta, R.L. Ellis-Davies, G.C.R. and MacVicar, B.A. (2008) Brian metabolism dictates the polarity of astrocyte control over arterioles. Nature. 456(7223):745-9. PDF

Thompson, R.J., Jackson, M.F., Olah, M.E., Rungta, R. L., Hines, D.J., Beazely, M.A., MacDonald, J.F. & MacVicar, B.A. (2008). Activation of Pannexin-1 hemmichannels augments aberrant bursting in the hippocampus. Science, 322, 1555-1559. PDF

Masanori Tachikawa

Tachikawa M., Fujinawa J., Takahashi M., Kasai Y., Fukaya M., Sakai K., Yamazaki M., Tomi M., Watanabe M., Sakimura K., Terasaki T. and Hosoya K. (2008) Expression and possible role of creatine transporter in the brain and at the blood-cerebrospinal fluid barrier as a transporting protein of guanidinoacetate, an endogenous convulsant. Journal of Neurochemistry 107, 768-778.

Tachikawa M., Kasai Y., Takahashi M., Fujinawa J., Kitaichi K., Terasaki T. and Hosoya K. (2008) The blood-cerebrospinal fluid barrier is a major pathway of cerebral creatinine clearance: involvement of transporter-mediated process. Journal of Neurochemistry 107, 432-442.

Tachikawa M., Toki H., Tomi M. and Hosoya K. (2008) Gene expression profiles of ATP-binding cassette transporter A and C subfamilies in mouse retinal vascular endothelial cells. Microvascular Research 75, 68-72.

Yamada K., Hashimoto T., Yabuki C., Nagae Y., Tachikawa M., Strickland D. K., Liu Q., Bu G., Basak J. M., Holtzman D. M., Ohtsuki S., Terasaki T. and Iwatsubo T. (2008) The low density lipoprotein receptor-related protein 1 mediates uptake of amyloid beta peptides in an in vitro model of the blood-brain barrier cells. The Journal of Biological Chemistry 283, 34554-34562.

Akanuma S., Ohtsuki S., Doi Y., Tachikawa M., Ito S., Hori S., Asashima T., Hashimoto T., Yamada K., Ueda K., Iwatsubo T. and Terasaki T. (2008) ATP-binding cassette transporter A1 (ABCA1) deficiency does not attenuate the brain-to-blood efflux transport of human amyloid-beta peptide (1-40) at the blood-brain barrier. Neurochemistry International 52, 956-961.

Tomi M., Tajima A., Tachikawa M. and Hosoya K. (2008) Function of taurine transporter (Slc6a6/TauT) as a GABA transporting protein and its relevance to GABA transport in rat retinal capillary endothelial cells. Biochimica et Biophysica acta 1778, 2138-2142.

Hosoya K., Fujita K. and Tachikawa M. (2008) Involvement of reduced folate carrier 1 in the inner blood-retinal barrier transport of methyltetrahydrofolate. Drug Metabolism and Pharmacokinetics 23, 285-292.

Hosoya K., Nakamura G., Akanuma S., Tomi M. and Tachikawa M. (2008) Dehydroascorbic acid uptake and intracellular ascorbic acid accumulation in cultured Muller glial cells (TR-MUL). Neurochemistry International 52, 1351-1357.

Hosoya K., Kyoko H., Toyooka N., Kato A., Orihashi M., Tomi M. and Tachikawa M. (2008) Evaluation of amino acid-mustard transport as L-type amino acid transporter 1 (LAT1)-mediated alkylating agents. Biological & Pharmaceutical Bulletin 31, 2126-2130.

Hosoya K. I., Makihara A., Tsujikawa Y., Yoneyama D., Mori S., Terasaki T., Akanuma S. I., Tomi M. and Tachikawa M. (2008) Roles of inner Blood-Retinal Barrier Organic Anion Transporter 3 (OAT3) in the Vitreous/Retina-to-Blood Efflux Transport of p-Aminohippuric Acid, Benzylpenicillin, and 6-Mercaptopurine. The Journal of Pharmacology and Experimental Therapeutics.

Tachikawa M., Okayasu S. and Hosoya K. (2007) Functional involvement of scavenger receptor class B, type I, in the uptake of alpha-tocopherol using cultured rat retinal capillary endothelial cells. Molecular Vision 13, 2041-2047.

Tomi M., Arai K., Tachikawa M. and Hosoya K. (2007) Na(+)-independent choline transport in rat retinal capillary endothelial cells. Neurochemical Research 32, 1833-1842.

Fujiyoshi M., Ohtsuki S., Hori S., Tachikawa M. and Terasaki T. (2007) 24S-hydroxycholesterol induces cholesterol release from choroid plexus epithelial cells in an apical- and apoE isoform-dependent manner concomitantly with the induction of ABCA1 and ABCG1 expression. Journal of Neurochemistry 100, 968-978.

Asashima T., Hori S., Ohtsuki S., Tachikawa M., Watanabe M., Mukai C., Kitagaki S., Miyakoshi N. and Terasaki T. (2006) ATP-binding cassette transporter G2 mediates the efflux of phototoxins on the luminal membrane of retinal capillary endothelial cells. Pharmaceutical Research 23, 1235-1242.

Nagase K., Tomi M., Tachikawa M. and Hosoya K. (2006) Functional and molecular characterization of adenosine transport at the rat inner blood-retinal barrier. Biochimica et Biophysica Acta 1758, 13-19.

Tachikawa M., Watanabe M., Hori S., Fukaya M., Ohtsuki S., Asashima T. and Terasaki T. (2005) Distinct spatio-temporal expression of ABCA and ABCG transporters in the developing and adult mouse brain. Journal of Neurochemistry 95, 294-304.

Bhongsatiern J., Ohtsuki S., Tachikawa M., Hori S. and Terasaki T. (2005) Retinal-specific ATP-binding cassette transporter (ABCR/ABCA4) is expressed at the choroid plexus in rat brain. Journal of Neurochemistry 92, 1277-1280.

Nakashima T., Tomi M., Tachikawa M., Watanabe M., Terasaki T. and Hosoya K. (2005) Evidence for creatine biosynthesis in Muller glia. Glia 52, 47-52.

Tomi M., Mori M., Tachikawa M., Katayama K., Terasaki T. and Hosoya K. (2005) L-type amino acid transporter 1-mediated L-leucine transport at the inner blood-retinal barrier. Investigative Ophthalmology & Visual Science 46, 2522-2530.

Tachikawa M., Fukaya M., Terasaki T., Ohtsuki S. and Watanabe M. (2004) Distinct cellular expressions of creatine synthetic enzyme GAMT and creatine kinases uCK-Mi and CK-B suggest a novel neuron-glial relationship for brain energy homeostasis. The European Journal of Neuroscience 20, 144-160.

Hori S., Ohtsuki S., Tachikawa M., Kimura N., Kondo T., Watanabe M., Nakashima E. and Terasaki T. (2004) Functional expression of rat ABCG2 on the luminal side of brain capillaries and its enhancement by astrocyte-derived soluble factor(s). Journal of Neurochemistry 90, 526-536.

Nakashima T., Tomi M., Katayama K., Tachikawa M., Watanabe M., Terasaki T. and Hosoya K. (2004) Blood-to-retina transport of creatine via creatine transporter (CRT) at the rat inner blood-retinal barrier. Journal of Neurochemistry 89, 1454-1461.

Ohtsuki S., Tachikawa M., Takanaga H., Shimizu H., Watanabe M., Hosoya K. and Terasaki T. (2002) The blood-brain barrier creatine transporter is a major pathway for supplying creatine to the brain. J Cereb Blood Flow Metab 22, 1327-1335.
Deguchi Y., Okutsu H., Okura T., Yamada S., Kimura R., Yuge T., Furukawa A., Morimoto K., Tachikawa M., Ohtsuki S., Hosoya K. and Terasaki T. (2002) Internalization of basic fibroblast growth factor at the mouse blood-brain barrier involves perlecan, a heparan sulfate proteoglycan. Journal of Neurochemistry 83, 381-389.

Jingfei Zhang

Ning Zhou

Thompson, R.J, Zhou, N., & MacVicar, B.A. (2006). Ischemia opens neuronal gap junction hemichannels. BA. Science 12;312(5775):924-7. PDF

Brust, T.B., Cayabyab, F.S., Zhou, N. & MacVicar, B.A. (2006). Mmitogen-activated protein kinase contributes to adenosine A1-receptor-mediated synaptic depression in area CA1 of the rat hippocampus. Journal of Neuroscience, 26,12427-12438. PDF